4-year PhD studentship
on
"Exploring the secret metabolism of an antibiotic factory"
What? Four-year bursary PhD position, fully funded
When? Available from November 2007
Where? Department of Microbial Physiology, University of Groningen, The Netherlands
This project will be a unique collaboration between the
Microbial Physiology department and the Groningen Bioinformatics Centre
using a newly acquired state-of-art ultra-high resolution LTQ-Orbitrap
mass spectrometer in the Medical Biomics Facility to determine the
metabolome of Streptomyces coelicolor.
Project objectives
Comprehensively explore the cellular and secreted metabolome of
Streptomyces species to identify novel antibiotic biosynthesis
pathways, using ultra-high resolution Orbitrap mass spectrometry
Understand the fundamental changes of the metabolome during
the switch from primary to secondary metabolism, i.e. when antibiotics
are produced, in S. coelicolor, our model organism.
Requirements
Candidates should have training in biochemistry, microbiology,
and molecular biology. Experience in bioinformatics, and handling
Streptomyces, would be a plus.
Environment
The University of Groningen is one of the largest and oldest
research universities of the Netherlands. Its Microbial Physiology
department is one of the leading institutes of Microbiology in Europe.
It is part of the Groningen Biomolecular Sciences and Biotechnology
Institute (GBB), which houses 13 different research groups and provides
access to state-of-the-art research facilities to more than 100 PhD
students and 30 faculty members.
Research in the Microbial Physiology group focuses on
structure/function relationships of enzymes acting on carbohydrates,
and differentiation, regulation and metabolic engineering of antibiotic
production in Streptomyces. The Bioinformatics Centre is a major player
in the development of modern Systems Biology approaches.
Relevant publications: Breitling et al. (2006) Trends
Biotechnol. 24(12):543-8. Breitling et al. (2006): Metabolomics 2:
155-64. Hsiao et al. (2007) Microbiology 153:1394-404. Takano (2006)
Curr Opin Microbiol. 9:287-94.
Additional information and applications
You can apply for this job before September 16th, 2007. For further information and direct applications please contact:
Dr Eriko Takano
Microbial Physiology
University of Groningen
Kerklaan 30
9751 NN Haren, The Netherlands
Phone +31-(0)50-3632143
Fax +31-(0)50-3632154
Email e.takano@rug.nl
Dr Rainer Breitling
Groningen Bioinformatics Centre
University of Groningen
Kerklaan 30
9751 NN Haren, The Netherlands
Phone +31 (0)50-363-8088
Fax +31 (0)50-363-7976
Email r.breitling@rug.nl
Regards,
Adji Achmad Rinaldo Fernandes
Statistics Study Programme
FMIPA Brawijaya University
____________________________________________________________________________________
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