PhD-researcher in Cellular Immunology (1,0 fte) Utrecht University, Faculty
of Veterinary Medicine (Utrecht), 38 hours per week
Job description
------------------------------
The research position is part of a large research project of a Dutch
consortium on the restoration of a failing cellular stress response in aging
people and specific patient groups, funded by IOP-Genomics, SenterNovem. The
initial project, Helping Health: boosting the cellular defence system is now
in its fourth year, while a follow-up 4-year project (with the available
position) soon will start.
The consortium is a collaboration between the Faculty of Veterinary Medicine
and the Department of Chemistry (Cellular Protein Chemistry, Prof I.
Braakman) of Utrecht University, Biomolecular Chemistry, Radboud University
Nijmegen (Dr N.H. Lubsen) and Radiation and Stress Cell Biology, University
of Groningen (Prof H.H. Kampinga). Additionally, a group of 8 industrial
partners is involved.
In eukaryotes both the heat shock response and the unfolded protein response
provide cells normally with an increased set of chaperones (heat shock
proteins, Hsps) either to refold damaged cellular proteins or to target them
for degradation by the proteasome system or for degradation through
chaperone mediated autophagy. The latter pathway (including presentation via
MHC class II molecules) plays a role in the induction of regulatory CD4 T
cells reactive towards Hsps resulting in suppression of chronic inflammatory
diseases. Given the role of the stress system in immunity, a relative
deficiency of the stress response likely predisposes to chronic inflammatory
disease.
At the division of Immunology we wish to elucidate the effect of enhancing
the cellular stress response via induction of heat shock proteins within
immunological relevant cell types and the subsequent effect on immune
regulation and restoring immune homeostasis via regulatory T cell induction
both in in vitro studies and in experimental models of chronic inflammation,
such as arthritis and allergies.
Keywords: heat shock response, stress proteins, chronic inflammation,
regulatory T cells.
Requirements
------------------------------
Required education/skills:University Graduate
MSc degree in biology, biomedical sciences or veterinary medicine. We seek a
motivated candidate preferably with experience in immunology and cell
culture. Animal experimentation is part of this project.
Job type: Research / Advising
Workfield(s):
- Research trainees, non-tenured lecturers, researchers(Scientific
discipline: Health)
Organization
------------------------------
Utrecht University, Faculty of Veterinary Medicine
The division of Immunology, department of Infectious Diseases and
Immunology, Faculty of Veterinary Medicine, focuses on the initiation and
regulation of antigen-specific immune responses, looking at fundamental
aspects with applications in veterinary and human medicine.
We are looking for a: PhD-researcher in Cellular Immunology
Conditions of employment
------------------------------
Estimated maximum salary per month: eur 2000 - 2500
Salary: scale 10.
Maximum salary amount in Euro's a month 2502
Employment basis: Temporary for specified period
Duration of the contract: 1 year with the perspective of prolongation with
another 3 years
Maximum hours per week: 38
Additional conditions of employment:
We offer a full time appointment of one year with the perspective of
prolongation with another 3 years. The appointment should lead to a
dissertation.
The salary will range from € 1,956. - (first year) before tax, up to a
maximum of € 2,502.- (final year) per month (salary scale "P" Collective
Employment Agreement of the Dutch Universities). Secondary benefits, based
on the Collective Employment Agreement of the Dutch Universities are
excellent in general and include e.g. a pension scheme, flexible employment
conditions and salaries are supplemented with a holiday bonus of 8% and a
year-end bonus of 3% per year.
Additional Information
------------------------------
Additional information about the vacancy can be obtained from:
Dr R. van der Zee
Telephone number: (030) 253 3561
E-mail address: R.vanderzee@uu.nl
Or Dr F. Broere
Telephone number: (030) 253 4330
E-mail address: F.Broere@uu.nl
Or additional information can be obtained through one of the following
links:
- About the organization <http:///> (http:// <http:///>)
- About the department <http:///> (http:// <http:///>)
- About the function <http:///> (http:// <http:///>)
Application
------------------------------
You can apply for this job before 04-01-2008 (dd-mm-yyyy) by sending your
application to:
Faculty of Veterinary Medicine
the Personnel Department
Mr.A.H. Bloemers
Yalelaan 1
3584 CL Utrecht
the Netherlands
E-mail: vacatures1@vet.uu.nl<vacatures1@vet.uu.nl?subject=ApplicationPhD-researcher%20in%20Cellular%20Immunology%20%281,0fte%29>
When applying for this job always mention the vacancy number 70834.
[Non-text portions of this message have been removed]
INFO, TIPS BEASISWA, FAQ - ADS
Hanya ada di http://www.milisbeasiswa.com/
===============================
CARI KERJA?
Gabung dengan milis vacancy. Kirim email kosong ke vacancy-subscribe@yahoogroups.com.
http://www.groups.yahoo.com/group/vacancy
===============================
INGIN KELUAR DARI MILIS BEASISWA?
Kirim email kosong ke beasiswa-unsubscribe@yahoogroups.com
Yahoo! Groups Links
<*> To visit your group on the web, go to:
http://groups.yahoo.com/group/beasiswa/
<*> Your email settings:
Individual Email | Traditional
<*> To change settings online go to:
http://groups.yahoo.com/group/beasiswa/join
(Yahoo! ID required)
<*> To change settings via email:
mailto:beasiswa-digest@yahoogroups.com
mailto:beasiswa-fullfeatured@yahoogroups.com
<*> To unsubscribe from this group, send an email to:
beasiswa-unsubscribe@yahoogroups.com
<*> Your use of Yahoo! Groups is subject to:
Tidak ada komentar:
Posting Komentar