Rabu, 26 Desember 2007

[beasiswa] [INFO] Integrative cancer bioinformatics: Postdoc position.

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Integrative cancer bioinformatics: Postdoc position.

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About the position:

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Basic cancer research through the development of appropriate model systems

such as mice, rats and cell lines is a field of special interest within the

Netherlands Cancer Institute. Ultimately, the goal is to combine this

information with human tumor data in order to deliver personalised treatment

to patients.

Recent developments in high-throughput genomic technologies have made it

possible to significantly further this research by unraveling the role of

large numbers of genes in important cellular processes. These technologies

include, amongst other, high-throughput high content screening (HTHCS) and

insertional mutagenesis screens.

In HTHCS, a large RNAi library in combination with cell-based assays,

fluorescence-based reagents, automated fluorescence microscopy and image

analysis are employed to study complex cellular phenotypes. In HTHCS one can

study the consequence of inactivation of large numbers of individual genes,

in a collection of individual cells, measured by multiple cellular

parameters.

In retroviral insertional mutagenesis, retroviruses integrate in the genome

of (genetically manipulated) mice, causing tumors by either activating

oncogenes of de-activating tumor suppressors. By studying the genomic

distribution patterns of the viral integration sites and the gene expression

of associated tumors, valuable information about genes and pathways involved

in tumorigenesis can be obtained.

Each of these technologies generates large, heterogeneous, complex datasets.

Currently, many of these datasets are simply employed to extract an

interesting new hit (e.g. a putative new oncogene) from a screen. By

performing an integrative analysis of the data we want to work towards

developing a 'systems level' understanding of the pathways and processes

involved in tumorigenesis. The computational challenges that need to be

addressed include the development of: 1) integrative models for 'experiment

specific' data and 'experiment independent' data to identify pathways and

interactions between pathways relevant to tumor development; 2) approaches

to associate (perturbations to) the identified pathways to phenotypic

outcomes; 3) cross-species comparisons to translate findings from model

systems (cell lines and mouse models) to the human system, and integration

of the findings from model systems with data from human tumors to predict

outcome and therapy response.

About the candidate - requirements:

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Ph.D in a relevant computational discipline such as Computer Science,

Statistics, Engineering, Applied Mathematics or Physics with experience in

Bioinformatics and/or Machine learning. Applicants that hold a Ph.D in the

life sciences, but with substantial experience in bioinformatics are also

encouraged to apply. The researcher appointed in this position will function

as a liaison between the Bioinformatics group and the research groups within

the Netherlands Cancer Institute performing the screens.

About the employer:

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The position is embedded within the Bioinformatics and statistics group lead

by Dr Lodewyk Wessels (http://bioinformatics.nki.nl). This group closely

collaborates with the groups of Drs Rene Bernards, Roderick Beijerbergen,

Anton Berns, Maarten van Lohuizen and Laura van 't Veer on the topics listed

above. The candidate will also be closely interacting with these groups on

the relevant topics. Research in the Netherlands Cancer Institute covers all

major areas of cancer research, with special emphasis on mouse models, mouse

(reverse) genetics, cell biology, immunology, translational research

requiring close collaboration between clinical and basic scientists and

epidemiology and psychosocial cancer research.

Employment conditions:

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The employment conditions follow general employment rules as laid down in

the 'CAO' for hospitals. The salary will be determined depending on

education and experience.

Want to find out more?

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For further information about the position please contact Dr. Lodewyk

Wessels, tel. +31 20 512 7987 or e-mail: l.wessels@nki.nl

How to apply:

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Applications for this position should include a Curriculum Vita with the

names and contact information of two professional references that can be

contacted for further information.

Send applications to:

The Personnel Department

The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital

Plesmanlaan 121

1066 CX Amsterdam

The Netherlands, or via email to work@nki.nl.

L.F.A.Wessels, Ph.D

Bioinformatics and Statistics

The Netherlands Cancer Institute

Plesmanlaan 121, 1066 CX Amsterdam

The Netherlands

Tel: +31 (0)20 5127987

Fax: +31 (0)20 6691383

Mobile: +31 (0)634485714

http://bioinformatics.nki.nl/



Setia Pramana
Bioinformatics Research Group
Center for Statistics
Hasselt University
Agoralaan - building D
3590 Diepenbeek
Belgium

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