http://www.rug.nl/gbb/research/researchgroups/bioinformatics/vacancies
Vacancy PhD Studentship on Complex Trait Analysis
What? Four-year bursary PhD position, fully funded
When? Available from January 2008
Job description
Project 1: The aim of this PhD position is to help unravel the genetic
basis of agriculturally/evolutionary important traits using
association- and linkage mapping approaches. The prospective student
will be involved in the analysis of data from a large, densely
genotyped natural collection of the flowering plant Arabidopsis
thaliana and a novel multi-family panel of recombinant inbred lines.
The nature and magnitude of these data will provide an unprecedented
high-resolution picture of the genetic variation underlying complex
phenotypes and will make it possible to systematically integrate
information from natural as well as experimental populations. The task
is to build an analytical/computational framework to facilitate such
an integrative analysis. As an extension, different types of –omics
data will be collected from these populations, which will then be used
to reconstruct the molecular networks that link genetic variation to
phenotypic variation.
Project 2: DNA methylation is an epigenetic mechanism that leads to
changes in gene expression which can be inherited through mitosis, and
even through meiosis in some instances. The impact of differential
methylation on the variability in complex quantitative traits at the
population level is an area of research that is vastly under-explored.
The aim of this novel project is to map methylation loci that
influence complex phenotypes using tiling array technology. The
student will be involved in the computer implementation of statistical
methods and is also expected to make creative contributions to the
conceptual development of this project.
Requirements
You are a university graduate at MSc level in one of the following
disciplines: bioinformatics, statistics, computer science,
mathematics, theoretical biology, quantitative genetics, physics, or
mathematics. You are expected to have an excellent academic record
(supply a list of examination marks from your university study) and be
curious, creative and ambitious. You should be able to write
scientific articles and reports (to be proven by your graduation
thesis or another comparable report) and be fluent in the English
language.
Additional information and applications
You can apply for this job until we have found a suitable candidate.
For further information and direct applications please contact:
Prof. dr. Ritsert Jansen
Groningen Bioinformatics Centre
University of Groningen
Kerklaan 30
9751 NN Haren, The Netherlands
Phone +31 (0)50-363-8089
Fax +31 (0)50-363-7976
Email r.c.jansen@rug.nl
Dr Frank Johannes
Groningen Bioinformatics Centre
University of Groningen
Kerklaan 30
9751 NN Haren, The Netherlands
Phone +31 (0)50-363-8082
Fax +31 (0)50-363-7976
Email f.johannes@rug.nl
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