*Identifying potential therapeutic targets in non-melanoma skin cancer - a
devastating complication of the genetic skin disease dystrophic
epidermolysis bullosa (DEB)*
Certain genetic skin diseases predispose to developing non melanoma skin
cancer. Recessive dystrophic epidermolysis bullosa (RDEB) is a devastating
genetic skin disease characterised by chronic erosions and blistering of the
skin. Not only do patients suffer from continual trauma induced skin
fragility, but are at a huge increased risk of developing Squamous cell
carcinoma (SCC). Unlike spontaneously arising SCC in the general population,
RDEB SCC are highly aggressive and prone to metastasis, with 55% of all
patients dying before the age of 40 years from this complication.
A three-year PhD studentship funded by DEBRA is available immediately to
join Dr Andrew South and the EB team at Dundee University, who have been
working towards genetic characterisation of RDEB SCC. Using a combination of
Affymetrix 10K genomic SNP mapping arrays and Illumina sentrix bead
expression arrays, genetic changes have been identified that are specific to
SCC development in both RDEB and non-RDEB individuals. This project will
follow up a number of candidate genetic loci identified in our initial
screens, as well as offering the opportunity to be involved in extending the
SNP genomic mapping using higher density 330K arrays and a larger sample set
with a view to identifying pathways and targets important in the development
of metastatic SCC.
Applications are invited from well-motivated candidates with at least an
upper second class honours degree in a relevant discipline. Candidates with
Masters degrees are also encouraged to apply. An ability to demonstrate
practical skills in cell or molecular biology would be an advantage. The
successful candidate will work in modern laboratories within the Division of
Surgery & Oncology, which is part of the School of Medicine, based at
Ninewells Hospital, Dundee. For an informal discussion, please contact the
lead project supervisor Dr Andrew South, tel: 01382 496432; email:
a.p.south@dundee.ac.uk.
The studentship pays tuition fees at UK/EU rate plus a maintenance stipend
of £12,600 per annum. Non-EU applicants will have to fund the difference
between home and oversees tuition fees themselves, approximately £8000 per
annum for 3 years.
Enquiries about the PhD programme at Dundee can be accessed at
http://www.dundee.ac.uk/cgi-bin/cgiwrap/cafranks/postgrad-research/frameindex.pl?sid=
Details of the work funded by DEBRA can be found at
http://www.debra.org.uk/research/
Applications including a full CV, letter of application (2 copies) outlining
suitability for the post and email contacts of two academic referees should
be addressed to Dr Irene Allan, tel: 01382 632196; email:
i.m.allan@dundee.ac.uk
*Applications by email will not be accepted. Closing date for applications
is 12 October 2007.*
[Non-text portions of this message have been removed]
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