Bacteriology and Immunology
*Science at the service of safe food production and animal health*
The Veterinary and Agrochemical Research Centre (VAR) is a Federal Public
Scientific Institution located on two campuses at Uccle and Tervuren, near
Brussels. In the framework of sustainable and socially acceptable
agriculture, the VAR, through scientific research, expert advice, and the
provision of services, contributes to a pro-active policy as regards safe
food production, animal health, and public health on the federal and
international levels.
To fulfill this task, 60 scientific and 150 technical staff are active in
applied research in the fields of transmissible animal diseases, and of
safety of animal and crop products. To support its growth and research
activities carried out at the Department of Bacteriology and Immunology, VAR
is currently seeking candidates for a PhD position.
*Framework and tasks*
Paratuberculosis or Johne's disease is an enzootic bacterial disease in
ruminants, due to Mycobacterium avium subsp. paratuberculosis (Map),
characterised by a chronic and fatal diahrrea. Its prevalence has reached
endemicity in European dairy herds and in the sheep, goat and deer farming
sectors, with 70-80% herd prevalence in some regions. Paratuberculosis is
also responsible for persistant environmental contamination of pastures and
water catchment areas. Current diagnostic methods lack sensitivity, and
current vaccines have little impact on the prevalence of infection;
therefore both require improvement for disease control.
The aim of this research is to explore and optimise the diagnostic and
vaccine potential of recently identified Map antigens in cattle. For this
purpose diagnostic antigen candidates will be targeted to Antigen Presenting
Cell (APC) surface receptors in a recombinant fusion strategy to enhance
antigen in vitro uptake and presentation, and vaccine candidates will be
targeted to cattle dendritic cell surface markers to enhance and modulate
antigen presentation.
The research supports ongoing programs on M. bovis diagnosis and Map antigen
discovery at the Veterinary Agrochemical Research Centre, and should lead to
a PhD at Université Libre de Bruxelles. It will be carried out in both
institutions under joint supervision of Dr M. Govaerts, VAR, and Prof dr M.
Moser, ULB, in collaboration with external partners. The candidate will be
recruited by VAR under a one-year, twice renewable research contract.
*Profile*
- Master in Life Sciences, Bio-Engineering, Veterinary Medicine or another
relevant field
- Written/spoken fluency in either English or French.
- Successful candidates will have the ability to work in high autonomy
within a multilingual group.
*Contact details*
- Dr Marc Govaerts, Dept. Bacteriology & Immunology, Veterinary and
Agrochemical Research Centre (CODA-CERVA), Groeselenberg 99, B-1180 Uccle,
Belgium. Tel : +32-2-3790443; Fax : +32-2-3790679; email : magov@var.fgov.be;
- homepages: http://www.var.fgov.be/section_immunology_fr.php and
http://www.ulb.ac.be/rech/inventaire/unites/ULB139.html
*Start date:* 01-Feb-2008, preferably 01-Jan-2008
*Application
*Please send your curriculum vitae, motivation, relevant research
experience, study curriculum with rankings, English/French proficiency (for
foreign students), pdf of diploma and transcripts (translation if
necessary), and name/e-mail (coordinates) of 2 reference persons, to
magov@var.fgov.be
*Further Details*<http://www.jobs.ac.uk/jobs/AH256/PhD_Position/www.var.fgov.be/>
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